ST-1936 (2-methyl-5-chloro-N,N-dimethyltryptamine) is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT6 receptor agonist, with a Ki of 13 nM, and much weaker action at 5-HT2B and 5-HT7 subtypes. In animal studies it has been found to increase dopamine and noradrenaline mediated signalling but decreases glutamatergic transmission, and has antidepressant effects.[1][2][3][4]
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| Formula | C13H17ClN2 |
| Molar mass | 236.74 g·mol−1 |
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See also
editReferences
edit- ^ Valentini V, Frau R, Bordi F, Borsini F, Di Chiara G (March 2011). "A microdialysis study of ST1936, a novel 5-HT6 receptor agonist". Neuropharmacology. 60 (4): 602–8. doi:10.1016/j.neuropharm.2010.12.006. PMID 21185318. S2CID 26758667.
- ^ Riccioni T, Bordi F, Minetti P, Spadoni G, Yun HM, Im BH, et al. (July 2011). "ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors". European Journal of Pharmacology. 661 (1–3): 8–14. doi:10.1016/j.ejphar.2011.04.028. PMID 21549693.
- ^ Tassone A, Madeo G, Schirinzi T, Vita D, Puglisi F, Ponterio G, et al. (September 2011). "Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission". Neuropharmacology. 61 (4): 632–7. doi:10.1016/j.neuropharm.2011.05.004. PMID 21619890. S2CID 24612187.
- ^ Scheggi S, Marchese G, Borsini F, Bordi F, De Montis MG (October 2011). "Effects of the 5-HT(6) receptor agonist ST 1936 on depression- and anhedonia-like experimental models". Behavioural Brain Research. 224 (1): 35–43. doi:10.1016/j.bbr.2011.05.019. PMID 21645553. S2CID 6270975.