Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene.[5] This enzyme adds a N-acetylneuraminic acid (Neu5Ac, a sialic acid) to an O-linked N-acetylgalactosamine (GalNAc) on a peptide/proteins (also called Tn antigen) with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers threonine over serine containing GalNAc residues.[6][7]

ST6GALNAC1
Identifiers
AliasesST6GALNAC1, HSY11339, SIAT7A, ST6GalNAcI, STYI, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
External IDsOMIM: 610138; MGI: 1341826; HomoloGene: 7937; GeneCards: ST6GALNAC1; OMA:ST6GALNAC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001289107
NM_018414

NM_011371

RefSeq (protein)

NP_001276036
NP_060884

NP_035501

Location (UCSC)Chr 17: 76.62 – 76.64 MbChr 11: 116.66 – 116.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000070526Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009588Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1".
  6. ^ Mehta AY, Veeraiah RK, Dutta S, Goth CK, Hanes MS, Gao C, et al. (June 2020). "Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries". Cell Chemical Biology. 27 (9): 1207–1219.e9. doi:10.1016/j.chembiol.2020.06.007. PMC 7556346. PMID 32610041.
  7. ^ Yoshimura Y, Denda-Nagai K, Takahashi Y, Nagashima I, Shimizu H, Kishimoto T, et al. (November 2019). "Products of Chemoenzymatic Synthesis Representing MUC1 Tandem Repeat Unit with T-, ST- or STn-antigen Revealed Distinct Specificities of Anti-MUC1 Antibodies". Scientific Reports. 9 (1): 16641. Bibcode:2019NatSR...916641Y. doi:10.1038/s41598-019-53052-1. PMC 6851390. PMID 31719620.

Further reading

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