Signal-transducing adaptor protein 1 is a protein that in humans is encoded by the STAP1 gene.[5][6][7]

STAP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSTAP1, BRDG1, STAP-1, signal transducing adaptor family member 1
External IDsOMIM: 604298; MGI: 1926193; HomoloGene: 8103; GeneCards: STAP1; OMA:STAP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012108
NM_001317769

NM_019992
NM_001310639

RefSeq (protein)

NP_001304698
NP_036240

NP_001297568
NP_064376

Location (UCSC)Chr 4: 67.56 – 67.61 MbChr 5: 86.22 – 86.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart.[7]

Interactions

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STAP1 has been shown to interact with C19orf2.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000035720Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029254Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y, Yamanaka T, Ikeda U, Shimada K, Ozawa K, Mano H (Nov 1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase". Proc Natl Acad Sci U S A. 96 (21): 11976–81. Bibcode:1999PNAS...9611976O. doi:10.1073/pnas.96.21.11976. PMC 18397. PMID 10518561.
  6. ^ Masuhara M, Nagao K, Nishikawa M, Sasaki M, Yoshimura A, Osawa M (Mar 2000). "Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains". Biochem Biophys Res Commun. 268 (3): 697–703. doi:10.1006/bbrc.2000.2223. PMID 10679268.
  7. ^ a b "Entrez Gene: BRDG1 BCR downstream signaling 1".
  8. ^ Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W (Nov 2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. Bibcode:2003Sci...302.1208G. doi:10.1126/science.1088401. PMID 14615539. S2CID 26836888.

Further reading

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