StAR-related lipid transfer protein 10 (STARD10 ) or PCTP -like proteinprotein that in humans is encoded by the STARD10 gene .[ 5] [ 6] START domain . As part of the StarD2 subfamily, StarD10 can transport the lipids phosphatidylcholine and phosphatidylethanolamine between membranes in solution.[ 7] Casein kinase II phosphorylates the protein on its serine at position 184.[ 8]
The function of StarD10 in the cell is not yet understood. Its expression is associated with cancer, but the nature of its role is unclear. Most recent data indicate that loss of StarD10 expression in breast cancer is associated with poor outcomes in patients.[ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000214530 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030688 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer . 76 (5): 652–8. doi :10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P . PMID 9610721 . S2CID 916155 . ^ "Entrez Gene: STARD10 START domain containing 10" .^ Olayioye MA, Vehring S, Müller P, Herrmann A, Schiller J, Thiele C, Lindeman GJ, Visvader JE, Pomorski T (July 2005). "StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein" . The Journal of Biological Chemistry . 280 (29): 27436–42. doi :10.1074/jbc.M413330200 PMID 15911624 . ^ Olayioye MA, Buchholz M, Schmid S, Schöffler P, Hoffmann P, Pomorski T (August 2007). "Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity" . The Journal of Biological Chemistry . 282 (31): 22492–8. doi :10.1074/jbc.M701990200 PMID 17561512 . ^ Murphy NC, Biankin AV, Millar EK, McNeil CM, O'Toole SA, Segara D, Crea P, Olayioye MA, Lee CS, Fox SB, Morey AL, Christie M, Musgrove EA, Daly RJ, Lindeman GJ, Henshall SM, Visvader JE, Sutherland RL (March 2010). "Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status". International Journal of Cancer . 126 (6): 1445–53. doi :10.1002/ijc.24826 . PMID 19676041 . S2CID 24623598 .
Olayioye MA, Buchholz M, Schmid S, Schöffler P, Hoffmann P, Pomorski T (August 2007). "Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity" . The Journal of Biological Chemistry . 282 (31): 22492–8. doi :10.1074/jbc.M701990200 PMID 17561512 . Olayioye MA, Vehring S, Müller P, Herrmann A, Schiller J, Thiele C, Lindeman GJ, Visvader JE, Pomorski T (July 2005). "StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein" . The Journal of Biological Chemistry . 280 (29): 27436–42. doi :10.1074/jbc.M413330200 PMID 15911624 . Tabibiazar R, Wagner RA, Liao A, Quertermous T (December 2003). "Transcriptional profiling of the heart reveals chamber-specific gene expression patterns". Circulation Research . 93 (12): 1193–201. doi :10.1161/01.RES.0000103171.42654.DD . PMID 14576202 . S2CID 23716150 . Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics" . Genome Research . 10 (5): 703–13. doi :10.1101/gr.10.5.703 . PMC 310876 PMID 10810093 .
