StAR-related lipid transfer domain protein 7 (STARD7) or gestational trophoblastic tumor gene-1 (GTT1) is a lipid transporter that specifically binds and transports phosphatidylcholine between membranes.[5]
| STARD7 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | STARD7, GTT1, StAR related lipid transfer domain containing 7, FAME2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 616712; MGI: 2139090; HomoloGene: 32463; GeneCards: STARD7; OMA:STARD7 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function and tissue distribution
editStarD7 is found in the cytosol and associated with the mitochondrion.[5] When overproduced in the cell, mitochondrial levels of phosphatidylcholine rise.[5] High levels of the protein are found in tumor cells compared to normal cells, suggesting a role in cell proliferation.[6]
Structure
editThere are two forms of StarD7: StarD7-I and StarD7-II. The former is 295 amino acids long. StarD7-I possesses an additional 75 amino acids at its amino-terminus, which form a signaling sequence that targets it to the outer membrane of the mitochondrion.[5]
StarD7 contains a StAR-related transfer domain (START), from which it derives its name. Moreover, the protein is a member of the predominantly phosphatidylcholine transporter subfamily of START proteins, the StarD2 subfamily. It shares 25% sequence identity with StarD2.[5]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000084090 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027367 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c d e Horibata Y, Sugimoto H (March 2010). "StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondria". The Journal of Biological Chemistry. 285 (10): 7358–65. doi:10.1074/jbc.M109.056960. PMC 2844184. PMID 20042613.
- ^ Durand S, Angeletti S, Genti-Raimondi S (January 2004). "GTT1/StarD7, a novel phosphatidylcholine transfer protein-like highly expressed in gestational trophoblastic tumour: cloning and characterization". Placenta. 25 (1): 37–44. doi:10.1016/S0143-4004(03)00214-5. PMID 15013637.