STEAP1

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene.

STEAP1
Identifiers
Aliases	STEAP1, PRSS24, STEAP, six transmembrane epithelial antigen of the prostate 1, STEAP family member 1
External IDs	OMIM: 604415; MGI: 1917608; HomoloGene: 8256; GeneCards: STEAP1; OMA:STEAP1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q21.13 Start 90,154,456 bp End 90,164,829 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 A1|5 3.2 cM Start 5,786,317 bp End 5,799,326 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium cartilage tissue prostate tendon of biceps brachii Achilles tendon parietal pleura gonad mucosa of transverse colon abdominal fat gallbladder Top expressed in Epithelium of choroid plexus endothelial cell of lymphatic vessel lumbar spinal ganglion epithelium of lens molar hair follicle yolk sac adrenal gland Paneth cell iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ferric-chelate reductase (NADPH) activity metal ion binding transporter activity oxidoreductase activity cupric reductase activity channel activity Cellular component endosome membrane integral component of membrane cell-cell junction integral component of plasma membrane membrane endosome plasma membrane Biological process ion transport copper ion import iron ion homeostasis transmembrane transport iron ion import across cell outer membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26872 70358 Ensembl ENSG00000164647 ENSMUSG00000015652 UniProt Q9UHE8 Q9CWR7 RefSeq (mRNA) NM_012449 NM_027399 RefSeq (protein) NP_036581 NP_081675 Location (UCSC) Chr 7: 90.15 – 90.16 Mb Chr 5: 5.79 – 5.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.

Further reading

• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Hubert RS, Vivanco I, Chen E, et al. (2000). "STEAP: A prostate-specific cell-surface antigen highly expressed in human prostate tumors". Proc. Natl. Acad. Sci. U.S.A. 96 (25): 14523–8. doi:10.1073/pnas.96.25.14523. PMC 24469. PMID 10588738.
• Yang D, Holt GE, Velders MP, et al. (2001). "Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice". Cancer Res. 61 (15): 5857–60. PMID 11479226.
• Korkmaz KS, Elbi C, Korkmaz CG, et al. (2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". J. Biol. Chem. 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID 12095985.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rodeberg DA, Nuss RA, Elsawa SF, Celis E (2005). "Recognition of Six-Transmembrane Epithelial Antigen of the Prostate–Expressing Tumor Cells by Peptide Antigen–Induced Cytotoxic T Lymphocytes". Clin. Cancer Res. 11 (12): 4545–52. doi:10.1158/1078-0432.CCR-04-2235. PMC 1698136. PMID 15958640.