Serine/threonine kinase 33 is a protein that in humans is encoded by the STK33 gene.
STK33 was identified as a synthetic lethal gene in KRAS-dependent cell lines.[5]
STK33 has been considered as a target for reversible male contraceptives and the inhibitor CDD-2807 has been tested successfully in mice.[6]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000130413 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031027 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Spoonamore J, Weïwer M, Wei J, Guichard B, Ross NT, Masson K, et al. (2010). "Screen for Inhibitors of STK33 Kinase Activity". Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US). PMID 23658944.
- ^ "Drug causes reversible male contraception in mice". 10 June 2024.
External links
edit- STK33+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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