STK33

STK33
Identifiers
Aliases	STK33, serine/threonine kinase 33
External IDs	OMIM: 607670; MGI: 2152419; HomoloGene: 75307; GeneCards: STK33; OMA:STK33 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	8,594,289 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	109,038,288 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; anterior pituitary; ; bronchial epithelial cell; ; left testis; ; right testis; ; olfactory zone of nasal mucosa; ; sperm; ; gonad; ; ventricular zone; ; testicle;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; epithelium of bronchiole; ; spermatogonium; ; medial ganglionic eminence; ; embryo; ; embryo; ; Jacobson's organ; ; outer plexiform layer;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; ATP binding; kinase activity; protein serine/threonine kinase activity;
Cellular component	cytoplasm; perinuclear region of cytoplasm; intracellular anatomical structure; nucleus;
Biological process	protein autophosphorylation; protein phosphorylation; phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; intracellular signal transduction; signal transduction in response to DNA damage; mitotic DNA damage checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologs
	65975
	117229
	ENSG00000130413
	ENSMUSG00000031027
	Q9BYT3
	Q924X7
NM_001289058; NM_001289059; NM_001289061; NM_030906; NM_001352387;
	NM_001352388; NM_001352389; NM_001352390; NM_001352391; NM_001352392; NM_001352393; NM_001352394; NM_001352395; NM_001352396; NM_001352397; NM_001352398; NM_001352399
	NM_054103; NM_001355145
NP_001275987; NP_001275988; NP_001275990; NP_112168; NP_001339316;
	NP_001339317; NP_001339318; NP_001339319; NP_001339320; NP_001339321; NP_001339322; NP_001339323; NP_001339324; NP_001339325; NP_001339326; NP_001339327; NP_001339328
	NP_473444; NP_001342074
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine kinase 33 is a protein that in humans is encoded by the STK33 gene.

STK33 was identified as a synthetic lethal gene in KRAS-dependent cell lines.^[5]

STK33 has been considered as a target for reversible male contraceptives and the inhibitor CDD-2807 has been tested successfully in mice.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130413 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031027 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Spoonamore J, Weïwer M, Wei J, Guichard B, Ross NT, Masson K, et al. (2010). "Screen for Inhibitors of STK33 Kinase Activity". Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US). PMID 23658944.
^ "Drug causes reversible male contraception in mice". 10 June 2024.

External links

STK33+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130413 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031027 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid23658944-5] Spoonamore J, Weïwer M, Wei J, Guichard B, Ross NT, Masson K, et al. (2010). "Screen for Inhibitors of STK33 Kinase Activity". Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US). PMID 23658944.

[6] "Drug causes reversible male contraception in mice". 10 June 2024.

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