STRBP

Spermatid perinuclear RNA-binding protein is a protein that in humans is encoded by the STRBP gene.

STRBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DMY
Identifiers
Aliases	STRBP, HEL162, ILF3L, SPNR, p74, spermatid perinuclear RNA binding protein
External IDs	OMIM: 611138; MGI: 104626; HomoloGene: 7548; GeneCards: STRBP; OMA:STRBP - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q33.3 Start 123,109,500 bp End 123,268,586 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 B Start 37,373,240 bp End 37,593,871 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte primary visual cortex lateral nuclear group of thalamus Brodmann area 23 sperm ganglionic eminence endothelial cell parietal lobe postcentral gyrus epithelium of nasopharynx Top expressed in tail of embryo lacrimal gland genital tubercle zygote medial dorsal nucleus olfactory epithelium Rostral migratory stream medial geniculate nucleus spermatocyte secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding double-stranded RNA binding protein binding single-stranded RNA binding RNA binding microtubule binding tubulin binding Cellular component cytoplasm microtubule cytoskeleton nucleus manchette Biological process multicellular organism development mechanosensory behavior cell differentiation spermatogenesis spermatid development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55342 20744 Ensembl ENSG00000165209 ENSMUSG00000026915 UniProt Q96SI9 Q91WM1 RefSeq (mRNA) NM_001171137 NM_018387 NM_001376106 NM_001376107 NM_001376109 NM_009261 NM_176932 NM_001355259 NM_001379314 NM_001379315 NM_001379316 RefSeq (protein) NP_001164608 NP_060857 NP_001363035 NP_001363036 NP_001363038 NP_033287 NP_001342188 NP_001366243 NP_001366244 NP_001366245 Location (UCSC) Chr 9: 123.11 – 123.27 Mb Chr 2: 37.37 – 37.59 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Schumacher JM, Lee K, Edelhoff S, Braun RE (May 1995). "Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules". The Journal of Cell Biology. 129 (4): 1023–32. doi:10.1083/jcb.129.4.1023. PMC 2120489. PMID 7744952.
• Schumacher JM, Artzt K, Braun RE (July 1998). "Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice". Biology of Reproduction. 59 (1): 69–76. doi:10.1095/biolreprod59.1.69. PMID 9674995.
• Coolidge CJ, Patton JG (March 2000). "A new double-stranded RNA-binding protein that interacts with PKR". Nucleic Acids Research. 28 (6): 1407–17. doi:10.1093/nar/28.6.1407. PMC 111047. PMID 10684936.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Pires-daSilva A, Nayernia K, Engel W, Torres M, Stoykova A, Chowdhury K, Gruss P (May 2001). "Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities" (PDF). Developmental Biology. 233 (2): 319–28. doi:10.1006/dbio.2001.0169. hdl:11858/00-001M-0000-0012-F717-7. PMID 11336498.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.