Ubiquitin-associated and SH3 domain-containing protein B is a protein that in humans is encoded by the UBASH3B gene.[5][6][7]

UBASH3B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUBASH3B, STS-1, STS1, TULA-2, p70, TULA2, ubiquitin associated and SH3 domain containing B
External IDsOMIM: 609201; MGI: 1920078; HomoloGene: 13152; GeneCards: UBASH3B; OMA:UBASH3B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032873
NM_001363365

NM_176860
NM_001357412

RefSeq (protein)

NP_116262
NP_001350294

NP_789830
NP_001344341

Location (UCSC)Chr 11: 122.66 – 122.81 MbChr 9: 40.92 – 41.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that contains a ubiquitin associated protein domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154127Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032020Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Ohara O (Feb 2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
  6. ^ Carpino N, Kobayashi R, Zang H, Takahashi Y, Jou ST, Feng J, Nakajima H, Ihle JN (Oct 2002). "Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein". Mol Cell Biol. 22 (21): 7491–500. doi:10.1128/MCB.22.21.7491-7500.2002. PMC 135669. PMID 12370296.
  7. ^ a b "Entrez Gene: STS-1 Cbl-interacting protein Sts-1".

Further reading

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