SUPV3L1

ATP-dependent RNA helicase SUPV3L1, mitochondrial is an enzyme that in humans is encoded by the SUPV3L1 gene.

SUPV3L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RC3, 3RC8
Identifiers
Aliases	SUPV3L1, SUV3, Suv3 like RNA helicase
External IDs	OMIM: 605122; MGI: 2441711; HomoloGene: 2386; GeneCards: SUPV3L1; OMA:SUPV3L1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q22.1 Start 69,180,234 bp End 69,209,099 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B4 Start 62,264,988 bp End 62,285,517 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte apex of heart mucosa of transverse colon cerebellar hemisphere gastrocnemius muscle right testis left testis right hemisphere of cerebellum right lobe of liver Top expressed in otic placode saccule otic vesicle zygote secondary oocyte epiblast primary oocyte right ventricle brown adipose tissue morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding protein homodimerization activity helicase activity 3'-5' RNA helicase activity hydrolase activity, acting on acid anhydrides DNA helicase activity protein binding double-stranded RNA binding ATP binding hydrolase activity RNA binding Cellular component mitochondrial degradosome mitochondrial matrix mitochondrion mitochondrial nucleoid nucleus Biological process DNA recombination mitochondrial mRNA catabolic process mitochondrial ncRNA surveillance mitochondrial RNA 3'-end processing RNA catabolic process negative regulation of apoptotic process positive regulation of cell growth DNA duplex unwinding mitochondrial mRNA surveillance mitochondrion morphogenesis mitochondrial RNA surveillance positive regulation of mitochondrial RNA catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6832 338359 Ensembl ENSG00000156502 ENSMUSG00000020079 UniProt Q8IYB8 Q80YD1 RefSeq (mRNA) NM_001301683 NM_003171 NM_001323584 NM_001323585 NM_001323586 NM_001323587 NM_001323588 NM_181423 NM_001359806 RefSeq (protein) NP_001288612 NP_001310513 NP_001310514 NP_001310515 NP_001310516 NP_001310517 NP_003162 NP_852088 NP_001346735 Location (UCSC) Chr 10: 69.18 – 69.21 Mb Chr 10: 62.26 – 62.29 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Glatt H (December 2000). "Sulfotransferases in the bioactivation of xenobiotics". Chemico-Biological Interactions. 129 (1–2): 141–70. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739.
• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Minczuk M, Piwowarski J, Papworth MA, Awiszus K, Schalinski S, Dziembowski A, Dmochowska A, Bartnik E, Tokatlidis K, Stepien PP, Borowski P (December 2002). "Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA". Nucleic Acids Research. 30 (23): 5074–86. doi:10.1093/nar/gkf647. PMC 137961. PMID 12466530.
• Shu Z, Vijayakumar S, Chen CF, Chen PL, Lee WH (April 2004). "Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change". Biochemistry. 43 (16): 4781–90. doi:10.1021/bi0356449. PMID 15096047.
• Minczuk M, Lilpop J, Boros J, Stepien PP (June 2005). "The 5' region of the human hSUV3 gene encoding mitochondrial DNA and RNA helicase: promoter characterization and alternative pre-mRNA splicing". Biochimica et Biophysica Acta. 1729 (2): 81–7. doi:10.1016/j.bbaexp.2005.04.005. PMID 15919122.
• Szczesny RJ, Obriot H, Paczkowska A, Jedrzejczak R, Dmochowska A, Bartnik E, Formstecher P, Polakowska R, Stepien PP (June 2007). "Down-regulation of human RNA/DNA helicase SUV3 induces apoptosis by a caspase- and AIF-dependent pathway". Biology of the Cell. 99 (6): 323–32. doi:10.1042/BC20060108. PMID 17352692. S2CID 174431.

External links

• Overview of all the structural information available in the PDB for UniProt: Q8IYB8 (ATP-dependent RNA helicase SUPV3L1, mitochondria) at the PDBe-KB.