This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene demonstrates features of a housekeeping gene, being ubiquitously expressed, and the encoded protein has been localized to the nucleolus. The protein includes motifs found in both the mouse and fish orthologs, which suggests a putative function as a nucleolar-matrix protein with nucleic acid-binding properties, based on characteristics determined in mouse.[6]
Yon J, Jones T, Garson K, et al. (1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Hum. Mol. Genet. 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID8499913.
Magoulas C, Fried M (1996). "The Surf-6 gene of the mouse surfeit locus encodes a novel nucleolar protein". DNA Cell Biol. 15 (4): 305–16. doi:10.1089/dna.1996.15.305. PMID8639267.
Magoulas C, Zatsepina OV, Jordan PW, et al. (1998). "The SURF-6 protein is a component of the nucleolar matrix and has a high binding capacity for nucleic acids in vitro". Eur. J. Cell Biol. 75 (2): 174–83. doi:10.1016/s0171-9335(98)80059-9. PMID9548374.
Magoulas C, Fried M (2000). "Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus". Gene. 243 (1–2): 115–23. doi:10.1016/S0378-1119(99)00551-X. PMID10675619.
Angiolillo A, Russo G, Porcellini A, et al. (2002). "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts". Gene. 284 (1–2): 169–78. doi:10.1016/S0378-1119(02)00379-7. PMID11891058.
