SYCP3

Synaptonemal complex protein 3 is a protein that in humans is encoded by the SYCP3 gene. It is a component of the synaptonemal complex formed between homologous chromosomes during the prophase of meiosis.

SYCP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CPC
Identifiers
Aliases	SYCP3, COR1, SCP3, SPGF4, RPRGL4, synaptonemal complex protein 3
External IDs	OMIM: 604759; MGI: 109542; HomoloGene: 7964; GeneCards: SYCP3; OMA:SYCP3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q23.2 Start 101,728,648 bp End 101,739,472 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 C1 Start 88,295,431 bp End 88,309,098 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis secondary oocyte gonad sperm testicle buccal mucosa cell stromal cell of endometrium mucosa of transverse colon Achilles tendon Top expressed in seminiferous tubule spermatocyte spermatid ascending aorta zygote aortic valve epithelium of small intestine Gonadal ridge brown adipose tissue secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding Cellular component nucleus chromosome synaptonemal complex lateral element chromosome, centromeric region Biological process cell cycle male meiosis I cell division meiosis spermatogenesis spermatid development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50511 20962 Ensembl ENSG00000139351 ENSMUSG00000020059 UniProt Q8IZU3 P70281 RefSeq (mRNA) NM_001177948 NM_001177949 NM_153694 NM_011517 RefSeq (protein) NP_001171419 NP_001171420 NP_710161 NP_035647 Location (UCSC) Chr 12: 101.73 – 101.74 Mb Chr 10: 88.3 – 88.31 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Gene family

XLR/SYCP3/FAM9 domain Identifiers Symbol Cor1 Pfam PF04803 InterPro IPR006888 CATH 4cpc Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

SYCP3 is also known as COR1. It contains a conserved coiled-coil domain that is also found in the FAM9 (FAM9A, FAM9B) family of proteins, found on the human X chromosome.

Several SYCP3-like proteins are found on mice sex chromosomes. They are assigned names starting with Slx or Sly depending on the chromosome they are linked to. Slx/Slxl1 and Sly are neofunctionalized ones that have opposite effects on gene expression and epigenetic modifications, and each gene reduces the viability and mobility (via spindlin binding) of sperms containing the other sex chromosome, tilting the sex ratio to their own favor. Over time they are duplicated to balance out each other's effects.

Further reading

• Yuan L, Liu JG, Zhao J, Brundell E, Daneholt B, Höög C (January 2000). "The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility". Molecular Cell. 5 (1): 73–83. doi:10.1016/S1097-2765(00)80404-9. PMID 10678170.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, et al. (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Lee J, Iwai T, Yokota T, Yamashita M (July 2003). "Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis". Journal of Cell Science. 116 (Pt 13): 2781–90. doi:10.1242/jcs.00495. PMID 12759374. S2CID 11040339.
• Miyamoto T, Hasuike S, Yogev L, Maduro MR, Ishikawa M, Westphal H, Lamb DJ (November 2003). "Azoospermia in patients heterozygous for a mutation in SYCP3". Lancet. 362 (9397): 1714–9. doi:10.1016/S0140-6736(03)14845-3. PMID 14643120. S2CID 44513816.
• de Boer P, Giele M, Lock MT, de Rooij DG, Giltay J, Hochstenbach R, te Velde ER (2004). "Kinetics of meiosis in azoospermic males: a joint histological and cytological approach". Cytogenetic and Genome Research. 105 (1): 36–46. doi:10.1159/000078007. hdl:1874/11543. PMID 15218256. S2CID 26325415.
• Stouffs K, Lissens W, Tournaye H, Van Steirteghem A, Liebaers I (October 2005). "SYCP3 mutations are uncommon in patients with azoospermia". Fertility and Sterility. 84 (4): 1019–20. doi:10.1016/j.fertnstert.2005.04.033. PMID 16213863.
• Aarabi M, Modarressi MH, Soltanghoraee H, Behjati R, Amirjannati N, Akhondi MM (August 2006). "Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia". Fertility and Sterility. 86 (2): 325–31. doi:10.1016/j.fertnstert.2005.12.070. PMID 16824523.
• Sapkota G, Knockaert M, Alarcón C, Montalvo E, Brivanlou AH, Massagué J (December 2006). "Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways". The Journal of Biological Chemistry. 281 (52): 40412–9. doi:10.1074/jbc.M610172200. PMID 17085434.
• Martínez J, Bonache S, Carvajal A, Bassas L, Larriba S (October 2007). "Mutations of SYCP3 are rare in infertile Spanish men with meiotic arrest". Fertility and Sterility. 88 (4): 988–9. doi:10.1016/j.fertnstert.2006.11.163. PMID 17434513.

External links

• Overview of all the structural information available in the PDB for UniProt: Q8IZU3 (Human Synaptonemal complex protein 3) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: P70281 (Mouse Synaptonemal complex protein 3) at the PDBe-KB.