SYPL1

Synaptophysin-like protein 1 is a protein that in humans is encoded by the SYPL1 gene.

SYPL1
Identifiers
Aliases	SYPL1, H-SP1, SYPL, synaptophysin like 1
External IDs	OMIM: 616665; MGI: 108081; HomoloGene: 4915; GeneCards: SYPL1; OMA:SYPL1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.3 Start 106,090,503 bp End 106,112,576 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12 A3|12 13.87 cM Start 33,003,890 bp End 33,029,859 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx C1 segment germinal epithelium mucosa of paranasal sinus olfactory zone of nasal mucosa parotid gland gingival epithelium minor salivary glands mucosa of pharynx oral cavity Top expressed in spermatid conjunctival fornix corneal stroma ascending aorta parotid gland crypt of lieberkuhn of small intestine aortic valve seminal vesicula transitional epithelium of urinary bladder triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity syntaxin-1 binding Cellular component synaptic vesicle secretory granule cytoplasmic vesicle membrane membrane melanosome cytoplasmic vesicle integral component of synaptic vesicle membrane integral component of membrane integral component of plasma membrane extracellular exosome synaptic vesicle membrane Biological process chemical synaptic transmission transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6856 19027 Ensembl ENSG00000008282 ENSMUSG00000020570 UniProt Q16563 O09117 RefSeq (mRNA) NM_006754 NM_182715 NM_013635 NM_198710 RefSeq (protein) NP_006745 NP_874384 NP_001368839 NP_001368840 NP_001368841 NP_001368842 NP_001368844 NP_001368845 NP_001368846 NP_001368847 NP_001368848 NP_001368849 NP_001368850 NP_038663 NP_942003 Location (UCSC) Chr 7: 106.09 – 106.11 Mb Chr 12: 33 – 33.03 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Zhong CZ, Hayzer DJ, Runge MS (1992). "Molecular cloning of a cDNA encoding a novel protein related to the neuronal vesicle protein synaptophysin". Biochim. Biophys. Acta. 1129 (2): 235–8. doi:10.1016/0167-4781(92)90495-l. PMID 1730063.
• Leube RE (1994). "Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human". Differentiation. 56 (3): 163–71. doi:10.1046/j.1432-0436.1994.5630163.x. PMID 8034131.
• Haass NK, Kartenbeck MA, Leube RE (1996). "Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles". J. Cell Biol. 134 (3): 731–46. doi:10.1083/jcb.134.3.731. PMC 2120938. PMID 8707851.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Windoffer R, Borchert-Stuhlträger M, Haass NK, et al. (1999). "Tissue expression of the vesicle protein pantophysin". Cell Tissue Res. 296 (3): 499–510. doi:10.1007/s004410051310. PMID 10370136. S2CID 6765747.
• Brooks CC, Scherer PE, Cleveland K, et al. (2000). "Pantophysin is a phosphoprotein component of adipocyte transport vesicles and associates with GLUT4-containing vesicles". J. Biol. Chem. 275 (3): 2029–36. doi:10.1074/jbc.275.3.2029. PMID 10636906.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.