SYT3

Synaptotagmin-3 is a protein that in humans is encoded by the SYT3 gene.

SYT3
Identifiers
Aliases	SYT3, SytIII, synaptotagmin 3
External IDs	OMIM: 600327; MGI: 99665; HomoloGene: 9617; GeneCards: SYT3; OMA:SYT3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 50,621,307 bp End 50,639,881 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B3|7 28.83 cM Start 44,033,526 bp End 44,049,611 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in primary visual cortex superior frontal gyrus right hemisphere of cerebellum prefrontal cortex Brodmann area 9 right frontal lobe anterior cingulate cortex hippocampus proper gonad hypothalamus Top expressed in primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell CA3 field perirhinal cortex cerebellar cortex neural layer of retina Ileal epithelium entorhinal cortex lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function clathrin binding calcium ion binding metal ion binding calcium-dependent phospholipid binding syntaxin binding SNARE binding phosphatidylserine binding Cellular component integral component of membrane endosome transport vesicle membrane membrane cytoplasmic vesicle presynapse plasma membrane synapse exocytic vesicle Biological process positive regulation of dendrite extension cell differentiation calcium-ion regulated exocytosis calcium ion-regulated exocytosis of neurotransmitter regulation of calcium ion-dependent exocytosis vesicle fusion regulation of dopamine secretion synaptic vesicle exocytosis vesicle-mediated transport cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84258 20981 Ensembl ENSG00000213023 ENSMUSG00000030731 UniProt Q9BQG1 O35681 RefSeq (mRNA) NM_001160328 NM_001160329 NM_032298 NM_001114116 NM_016663 RefSeq (protein) NP_001153800 NP_001153801 NP_115674 NP_001153800.1 NP_001153801.1 NP_115674.1 NP_001107588 NP_057872 Location (UCSC) Chr 19: 50.62 – 50.64 Mb Chr 7: 44.03 – 44.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. Bibcode:1995Natur.375..594L. doi:10.1038/375594a0. PMID 7791877. S2CID 4265549.
• Fukuda M, Kanno E, Mikoshiba K (October 1999). "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X". The Journal of Biological Chemistry. 274 (44): 31421–7. doi:10.1074/jbc.274.44.31421. PMID 10531343.
• Gerona RR, Larsen EC, Kowalchyk JA, Martin TF (March 2000). "The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes". The Journal of Biological Chemistry. 275 (9): 6328–36. doi:10.1074/jbc.275.9.6328. PMID 10692432.
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.