SYT4

Synaptotagmin-4 is a protein that in humans is encoded by the SYT4 gene.

SYT4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UGK
Identifiers
Aliases	SYT4, HsT1192, synaptotagmin 4
External IDs	OMIM: 600103; MGI: 101759; HomoloGene: 7559; GeneCards: SYT4; OMA:SYT4 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) Band 18q12.3 Start 43,267,892 bp End 43,277,535 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18 B1|18 17.75 cM Start 31,570,861 bp End 31,580,459 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis endothelial cell cerebellar hemisphere Brodmann area 23 right hemisphere of cerebellum Brodmann area 46 middle temporal gyrus superior frontal gyrus superior vestibular nucleus islet of Langerhans Top expressed in lobe of cerebellum cerebellar vermis ventral tegmental area pineal gland dorsomedial hypothalamic nucleus habenula anterior amygdaloid area ventromedial nucleus paraventricular nucleus of hypothalamus lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding clathrin binding phosphatidylserine binding metal ion binding protein binding SNARE binding syntaxin-1 binding syntaxin binding syntaxin-3 binding protein homodimerization activity protein heterodimerization activity calcium-dependent phospholipid binding Cellular component integral component of membrane intracellular membrane-bounded organelle membrane synapse synaptic vesicle membrane cell junction perinuclear region of cytoplasm neuron projection dense core granule cytoplasmic vesicle dendrite Golgi apparatus vesicle axon plasma membrane synaptic vesicle integral component of Golgi membrane integral component of synaptic vesicle membrane secretory granule membrane dense core granule membrane somatodendritic compartment soma neuron projection terminus exocytic vesicle astrocyte projection microvesicle glutamatergic synapse integral component of neuronal dense core vesicle membrane Biological process cell differentiation brain development positive regulation of dendrite extension negative regulation of vesicle fusion neurotransmitter secretion exocytosis vesicle fusion calcium ion-regulated exocytosis of neurotransmitter memory positive regulation of glutamate secretion regulation of dopamine secretion regulation of endocytosis regulation of vesicle fusion negative regulation of catecholamine secretion positive regulation of calcium ion-dependent exocytosis negative regulation of neurotransmitter secretion negative regulation of short-term neuronal synaptic plasticity vesicle fusion with vesicle secretory granule maturation negative regulation of protein secretion negative regulation of retrograde trans-synaptic signaling by neuropeptide regulation of calcium ion-dependent exocytosis negative regulation of calcium ion-dependent exocytosis trans-synaptic signaling by BDNF, modulating synaptic transmission vesicle-mediated transport calcium-ion regulated exocytosis cellular response to calcium ion regulation of presynaptic dense core granule exocytosis negative regulation of dense core granule exocytosis positive regulation of dense core granule exocytosis negative regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6860 20983 Ensembl ENSG00000132872 ENSMUSG00000024261 UniProt Q9H2B2 P40749 RefSeq (mRNA) NM_020783 NM_009308 RefSeq (protein) NP_065834 NP_033334 Location (UCSC) Chr 18: 43.27 – 43.28 Mb Chr 18: 31.57 – 31.58 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Ullrich B, Li C, Zhang JZ, et al. (1995). "Functional properties of multiple synaptotagmins in brain". Neuron. 13 (6): 1281–91. doi:10.1016/0896-6273(94)90415-4. PMID 7993622. S2CID 23856449.
• Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
• Thomas DM, Ferguson GD, Herschman HR, Elferink LA (1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV". Mol. Biol. Cell. 10 (7): 2285–95. doi:10.1091/mbc.10.7.2285. PMC 25443. PMID 10397765.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Ferguson GD, Chen XN, Korenberg JR, Herschman HR (2001). "The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity". J. Biol. Chem. 275 (47): 36920–6. doi:10.1074/jbc.M005801200. PMID 10938284.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9H2B2 (Human Synaptotagmin-4) at the PDBe-KB.