SYT5

Synaptotagmin-5 is a protein that in humans is encoded by the SYT5 gene.

SYT5
Identifiers
Aliases	SYT5, synaptotagmin 5
External IDs	OMIM: 600782; MGI: 1926368; HomoloGene: 55722; GeneCards: SYT5; OMA:SYT5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.42|11p Start 55,171,196 bp End 55,180,289 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A1 Start 4,542,764 bp End 4,550,540 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex right frontal lobe cingulate gyrus anterior cingulate cortex nucleus accumbens caudate nucleus dorsolateral prefrontal cortex Brodmann area 9 putamen Brodmann area 10 Top expressed in superior frontal gyrus primary visual cortex entorhinal cortex dentate gyrus of hippocampal formation granule cell perirhinal cortex CA3 field tongue anterior amygdaloid area ventromedial nucleus lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function clathrin binding metal ion binding protein heterodimerization activity calcium-dependent phospholipid binding syntaxin binding SNARE binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylserine binding calcium ion binding Cellular component integral component of membrane endosome membrane synapse synaptic vesicle membrane cell junction soma recycling endosome membrane perinuclear region of cytoplasm neuron projection dense core granule cytoplasmic vesicle plasma membrane proximal neuron projection integral component of neuronal dense core vesicle membrane axon exocytic vesicle Biological process synaptic vesicle endocytosis chemical synaptic transmission vesicle fusion regulation of calcium ion-dependent exocytosis calcium ion-regulated exocytosis of neurotransmitter regulation of dopamine secretion synaptic vesicle exocytosis vesicle-mediated transport calcium-ion regulated exocytosis cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6861 53420 Ensembl ENSG00000129990 ENSMUSG00000004961 UniProt O00445 Q9R0N5 RefSeq (mRNA) NM_001297774 NM_003180 NM_016908 NM_001360421 NM_001360422 RefSeq (protein) NP_001284703 NP_003171 NP_001347350 NP_001347351 Location (UCSC) Chr 19: 55.17 – 55.18 Mb Chr 7: 4.54 – 4.55 Mb PubMed search
Wikidata
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Further reading

• Hudson AW, Birnbaum MJ (1995). "Identification of a nonneuronal isoform of synaptotagmin". Proc. Natl. Acad. Sci. U.S.A. 92 (13): 5895–9. Bibcode:1995PNAS...92.5895H. doi:10.1073/pnas.92.13.5895. PMC 41608. PMID 7597049.
• Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
• Fukuda M, Kanno E, Mikoshiba K (1999). "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X." J. Biol. Chem. 274 (44): 31421–7. doi:10.1074/jbc.274.44.31421. PMID 10531343.
• Craxton M, Goedert M (1999). "Alternative splicing of synaptotagmins involving transmembrane exon skipping". FEBS Lett. 460 (3): 417–22. doi:10.1016/S0014-5793(99)01382-4. PMID 10556508. S2CID 19207631.
• Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sreenath AS, Kumar KR, Reddy GV, et al. (2005). "Evidence for the association of synaptotagmin with glutathione S-transferases: implications for a novel function in human breast cancer". Clin. Biochem. 38 (5): 436–43. doi:10.1016/j.clinbiochem.2005.01.009. PMID 15820774.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.