SYT6

Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene.

SYT6
Identifiers
Aliases	SYT6, sytVI, synaptotagmin 6
External IDs	OMIM: 607718; MGI: 1859544; HomoloGene: 10301; GeneCards: SYT6; OMA:SYT6 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p13.2 Start 114,089,291 bp End 114,153,880 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.2 Start 103,482,547 bp End 103,552,885 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell ganglionic eminence nucleus accumbens hypothalamus tibialis anterior muscle caudate nucleus primary visual cortex putamen mucosa of ileum prefrontal cortex Top expressed in multiform layer of neocortex superior frontal gyrus olfactory bulb pretectal area Rostral migratory stream primary visual cortex lumbar spinal ganglion olfactory tubercle dentate gyrus of hippocampal formation granule cell embryo More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding protein homodimerization activity clathrin binding calcium-dependent protein binding metal ion binding protein binding identical protein binding calcium-dependent phospholipid binding syntaxin binding phosphatidylserine binding SNARE binding Cellular component cytoplasm integral component of membrane cytosol membrane perinuclear endoplasmic reticulum synapse synaptic vesicle membrane cell junction cytoplasmic vesicle plasma membrane extrinsic component of membrane glutamatergic synapse integral component of synaptic membrane exocytic vesicle Biological process acrosomal vesicle exocytosis acrosome reaction regulation of calcium ion-dependent exocytosis calcium ion-regulated exocytosis of neurotransmitter vesicle fusion presynaptic dense core vesicle exocytosis regulation of dopamine secretion synaptic vesicle exocytosis vesicle-mediated transport calcium-ion regulated exocytosis cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 148281 54524 Ensembl ENSG00000134207 ENSMUSG00000027849 UniProt Q5T7P8 Q9R0N8 RefSeq (mRNA) NM_001253772 NM_001270805 NM_205848 NM_001366223 NM_001366224 NM_001366225 NM_001366226 NM_001276676 NM_001276677 NM_001276679 NM_001276680 NM_001276681 NM_018800 RefSeq (protein) NP_001257734 NP_995320 NP_001240701 NP_001353152 NP_001353153 NP_001353154 NP_001353155 NP_001263605 NP_001263606 NP_001263608 NP_001263609 NP_001263610 NP_061270 Location (UCSC) Chr 1: 114.09 – 114.15 Mb Chr 3: 103.48 – 103.55 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.[supplied by OMIM]

Further reading

• Roggero CM, Tomes CN, De Blas GA, Castillo J, Michaut MA, Fukuda M, Mayorga LS (September 2005). "Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis". Developmental Biology. 285 (2): 422–35. doi:10.1016/j.ydbio.2005.07.007. PMID 16111671.
• Michaut M, De Blas G, Tomes CN, Yunes R, Fukuda M, Mayorga LS (July 2001). "Synaptotagmin VI participates in the acrosome reaction of human spermatozoa". Developmental Biology. 235 (2): 521–9. doi:10.1006/dbio.2001.0316. PMID 11437455.
• Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
• Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. Bibcode:1995Natur.375..594L. doi:10.1038/375594a0. PMID 7791877. S2CID 4265549.