SYTL4

Synaptotagmin-like protein 4 is a protein that in humans is encoded by the SYTL4 gene.

SYTL4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CSZ, 3FDW
Identifiers
Aliases	SYTL4, SLP4, synaptotagmin like 4
External IDs	OMIM: 300723; MGI: 1351606; HomoloGene: 8454; GeneCards: SYTL4; OMA:SYTL4 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq22.1 Start 100,674,491 bp End 100,732,123 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X E3 Start 132,837,134 bp End 132,882,561 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary body of uterus canal of the cervix left uterine tube pituitary gland anterior pituitary myometrium ectocervix smooth muscle tissue Top expressed in superior cervical ganglion islet of Langerhans zygote secondary oocyte primary oocyte pituitary gland blood epithelium of stomach cumulus cell ovary More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding clathrin binding metal ion binding protein binding calcium-dependent phospholipid binding syntaxin binding phospholipid binding neurexin family protein binding Cellular component endosome exocytic vesicle membrane transport vesicle membrane secretory granule nucleoplasm cytoplasmic vesicle presynapse extrinsic component of membrane microtubule organizing center cytosol plasma membrane platelet alpha granule membrane synapse Biological process negative regulation of insulin secretion multivesicular body sorting pathway positive regulation of protein secretion positive regulation of exocytosis intracellular protein transport exocytosis vesicle fusion regulation of calcium ion-dependent exocytosis calcium ion-regulated exocytosis of neurotransmitter platelet degranulation plasma membrane repair Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 94121 27359 Ensembl ENSG00000102362 ENSMUSG00000031255 UniProt Q96C24 Q9R0Q1 RefSeq (mRNA) NM_001129896 NM_001174068 NM_080737 NM_001290717 NM_001290718 NM_001290719 NM_013757 RefSeq (protein) NP_001123368 NP_001167539 NP_542775 NP_001357089 NP_001357090 NP_001357091 NP_001357092 NP_001357093 NP_001357094 NP_001357095 NP_001357096 NP_001357097 NP_001357098 NP_001277646 NP_001277647 NP_001277648 NP_038785 Location (UCSC) Chr X: 100.67 – 100.73 Mb Chr X: 132.84 – 132.88 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Wang J, Takeuchi T, Yokota H, Izumi T (1999). "Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells". J. Biol. Chem. 274 (40): 28542–8. doi:10.1074/jbc.274.40.28542. PMID 10497219.
• Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.
• Yi Z, Yokota H, Torii S, et al. (2002). "The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules". Mol. Cell. Biol. 22 (6): 1858–67. doi:10.1128/MCB.22.6.1858-1867.2002. PMC 135591. PMID 11865063.
• Zhao S, Torii S, Yokota-Hashimoto H, et al. (2002). "Involvement of Rab27b in the regulated secretion of pituitary hormones". Endocrinology. 143 (5): 1817–24. doi:10.1210/endo.143.5.8823. PMID 11956164.
• Torii S, Zhao S, Yi Z, et al. (2002). "Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a". Mol. Cell. Biol. 22 (15): 5518–26. doi:10.1128/MCB.22.15.5518-5526.2002. PMC 133943. PMID 12101244.
• Fukuda M, Kanno E, Saegusa C, et al. (2002). "Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells". J. Biol. Chem. 277 (42): 39673–8. doi:10.1074/jbc.M205349200. PMID 12176990.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fukuda M (2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". J. Biol. Chem. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ciufo LF, Barclay JW, Burgoyne RD, Morgan A (2005). "Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions". Mol. Biol. Cell. 16 (2): 470–82. doi:10.1091/mbc.E04-08-0685. PMC 545880. PMID 15563604.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Plaisance V, Abderrahmani A, Perret-Menoud V, et al. (2006). "MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells". J. Biol. Chem. 281 (37): 26932–42. doi:10.1074/jbc.M601225200. PMID 16831872.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.