Saint Denise (Dionysia, Dionisia, Denyse) may refer to:
- Saint Denise of Paris (or France)
- Saints Peter, Andrew, Paul, and Denise, martyred at Lampsacus (3rd century)
- Saints Denise, Dativa, Leontia, Tertius, Emilianus, Boniface, Majoricus, and Servus, martyred in Africa (5th century)
- Dionisia de Santa María Mitas Talangpaz, Philippine religious figure, Servant of God since 1999 while being considered for possible canonization as a saint