Saint Theodora may refer to:
- Theodora (6th century) (500–548), 6th century Byzantine (Eastern Roman) empress, wife of Justinian I, considered a saint by the Greek Orthodox Church
- Theodora (wife of Theophilos) (born 815), Byzantine (Eastern Roman) empress in the 9th century
- Theodora (Roman martyr) (died 120), 2nd-century Christian martyr and saint
- Theodora and Didymus (died 304), early Christian martyrs
- Theodora of Alexandria, Eastern Orthodox saint
- Theodora (10th century), servant of Basil the Younger
- Theodora of Arta (са. 1225 - after 1270) 13th century, Empress of Epirus
- Theodora of Sihla (1650–?), Romanian Christian Orthodox saint
- Théodore Guérin (1798–1856), French-American saint, founder of the Sisters of Providence of Saint Mary-of-the-Woods, Indiana