Sampedro is a surname, and may refer to:
- José Luis Sampedro (1917-2013), Spanish economist and novelist
- Matilde Muñoz Sampedro (1900-1969), Spanish actress
- Melchor García Sampedro (1821-1858), Spanish Dominican missionary and saint
- Edelmira Sampedro y Robato (1906-1994), Countess of Covadonga
- Frank Sampedro (born 1949), American musician
- Ramón Sampedro (1943-1998), Spanish fisherman who fought for right of assisted suicide