Sandrini is an Italian surname. Notable people with the surname include:
- Domenico Sandrini (1883–1973), Italian cross-country skier, Nordic combined skier, and ski jumper
- Luis Sandrini (1905–1980), prolific Argentine comic film actor and film producer
- Mattia Sandrini (born 1993), Italian footballer
- Peter Sandrini (born 1961), Italian-born translation theorist and terminologist