Sandrini is an Italian surname. Notable people with the surname include:

  • Domenico Sandrini (1883–1973), Italian cross-country skier, Nordic combined skier, and ski jumper
  • Luis Sandrini (1905–1980), prolific Argentine comic film actor and film producer
  • Mattia Sandrini (born 1993), Italian footballer
  • Peter Sandrini (born 1961), Italian-born translation theorist and terminologist