Santa Rosa de Lima (the name of Rose of Lima, the first American Roman Catholic saint) could refer to:
- Santa Rosa de Lima, Santa Catarina, Brazil
- Santa Rosa de Lima, Sergipe, Brazil
- Santa Rosa de Lima, La Unión, El Salvador
- Santa Rosa de Lima, Santa Rosa, Guatemala
- Santa Rosa de Lima (Villagrán), Guanajuato, Mexico
- Santa Rosa de Lima, New Mexico, USA, ruins near Abiquiu