Santiago Guzmán (born January 11, 1989, in San Miguel de Tucumán, Argentina) is an Argentinerugby union player. He plays in the lock position. In May 2010, he was selected in a squad of over 40 players to represent Argentina in the two test Summer tour of Argentina. He has previously captained the Argentina U20 team.
He join the Stade Français (Paris) in June 2010.