Schultheiss is a surname. Notable people with the surname include:
- Adrian Schultheiss (born 1988), Swedish figure skater
- Christina Schultheiß (1918-2016), German civil engineer, best known for her involvement in the Protestant church.
- Hans Schultheiss (1921–2013), Swiss rower
- Herman J. Schulteis (1818–1889), Wisconsin politician
- Joachim Ludwig Schultheiss von Unfriedt (1678–1753), German architect
- Louis A. Schultheiss (1925–2014), American academic