Scyllo-inosamine-4-phosphate amidinotransferase

In enzymology, a scyllo-inosamine-4-phosphate amidinotransferase (EC 2.1.4.2) is an enzyme that catalyzes the chemical reaction

scyllo-inosamine-4-phosphate amidinotransferase
Identifiers
EC no.2.1.4.2
CAS no.52227-63-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate

Thus, the two substrates of this enzyme are L-arginine and 1-amino-1-deoxy-scyllo-inositol 4-phosphate, whereas its two products are L-ornithine and 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the amidinotransferases. The systematic name of this enzyme class is L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase. Other names in common use include L-arginine:inosamine-P-amidinotransferase, inosamine-P amidinotransferase, L-arginine:inosamine phosphate amidinotransferase, and inosamine-phosphate amidinotransferase. This enzyme participates in streptomycin biosynthesis.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1BWD.

References

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  • Walker MS, Walker JB (1966). "Enzymic studies on the biosynthesis of streptomycin, transamidation of inosamine and streptamine derivatives". J. Biol. Chem. 241 (6): 1262–1269. doi:10.1016/S0021-9258(18)96769-4. PMID 5935341.