Seed of Destruction may refer to:
- "Seed of Destruction" (Space: 1999), the 13th episode of the second series of Space: 1999
- Hellboy: Seed of Destruction, the first Hellboy story arc
- EverQuest: Seeds of Destruction, an expansion to the MMORPG Everquest
This disambiguation page lists articles associated with the title Seed of Destruction.
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