Segatella sinensis
| Segatella sinensis | |
|---|---|
| Scientific classification | |
| Domain: | Bacteria |
| Phylum: | Bacteroidota |
| Class: | Bacteroidia |
| Order: | Bacteroidales |
| Family: | Prevotellaceae |
| Genus: | |
| Species: | S. sinensis |
| Binomial name | |
| Segatella sinensis Blanco-Miguez et al. (2023) | |
Segatella sinensis is a Gram-negative, anaerobic, non-spore-forming, non-motile bacterium.[1] The species belongs to the genus Segatella[2] and was previously identified as Segatella copri (also Prevotella copri) before being identified as a distinct species in 2023.
The Segatella genus dominates in individuals living in non-Westernized populations.[3][4][5] S. copri and S. sinensis frequently co-occur: both species are present in 13% of Westernized, and 79% of non-Westernized populations.[6]
S. sinensis, specifically, is also associated with the male sex.[6]
Phylogeny
[edit]S. sinensis was first identified as a distinct species in 2023, when the genetic diversity of Segatella copri was further investigated through the isolation of 44 distinct strains.[6] Seven distinct Segatella copri-related species were defined: S. sinensis, S. copri, S. brunsvicensis, S. brasiliensis, S. hominis, S. sanihominis, and S. sinica.
Locus of enterocyte effacement
[edit]S. sinensis contains the locus of enterocyte effacement (LEE): a pathogenicity island which encodes a secretion system proteins responsible for attaching to and damaging the intestinal lining.[7][8] LEE was absent in the other Segatella copri-derived species and can therefore be seen as a unique identifier.
Pathology
[edit]An overabundance of Segatella species has been linked to diseases such as rheumatoid arthritis in Westernized populations.[9][10] Other studies, however, have failed to establish the same association. Some studies even linked Segatella species to an improved metabolic health.[11][12] The exact effect of Segatella species on human health has therefore yet to be clarified.[13]
The presence of S. sinensis has been associated with a 60% reduced chance of visceral fat[6] and is negatively associated with the number of triglycerides and lipoprotein density. The bacterium has also been positively associated with healthy diet scores.[6]
References
[edit]- ↑ SHAH, HAROUN N.; COLLINS, DAVID M. (1990). "NOTES: Prevotella, a New Genus To Include Bacteroides melaninogenicus and Related Species Formerly Classified in the Genus Bacteroides". International Journal of Systematic and Evolutionary Microbiology. 40 (2). Microbiology Society: 205–208. doi:10.1099/00207713-40-2-205. ISSN 1466-5034. PMID 2223612.
- ↑ Hitch, Thomas C.A.; Bisdorf, Kevin; Afrizal, Afrizal; Riedel, Thomas; Overmann, Jörg; Strowig, Till; Clavel, Thomas (November 2022). "A taxonomic note on the genus Prevotella: Description of four novel genera and emended description of the genera Hallella and Xylanibacter". Systematic and Applied Microbiology. 45 (6) 126354. Bibcode:2022SyApM..4526354H. doi:10.1016/j.syapm.2022.126354. ISSN 0723-2020. PMID 36067550.
- ↑ Yatsunenko, Tanya; Rey, Federico E.; Manary, Mark J.; Trehan, Indi; Dominguez-Bello, Maria Gloria; Contreras, Monica; Magris, Magda; Hidalgo, Glida; Baldassano, Robert N.; Anokhin, Andrey P.; Heath, Andrew C.; Warner, Barbara; Reeder, Jens; Kuczynski, Justin; Caporaso, J. Gregory (2012-05-09). "Human gut microbiome viewed across age and geography". Nature. 486 (7402): 222–227. Bibcode:2012Natur.486..222Y. doi:10.1038/nature11053. ISSN 0028-0836. PMC 3376388. PMID 22699611.
- ↑ Schnorr, Stephanie L.; Candela, Marco; Rampelli, Simone; Centanni, Manuela; Consolandi, Clarissa; Basaglia, Giulia; Turroni, Silvia; Biagi, Elena; Peano, Clelia; Severgnini, Marco; Fiori, Jessica; Gotti, Roberto; De Bellis, Gianluca; Luiselli, Donata; Brigidi, Patrizia (2014-04-15). "Gut microbiome of the Hadza hunter-gatherers". Nature Communications. 5 (1) 3654. Bibcode:2014NatCo...5.3654S. doi:10.1038/ncomms4654. ISSN 2041-1723. PMC 3996546. PMID 24736369.
- ↑ De Filippo, Carlotta; Cavalieri, Duccio; Di Paola, Monica; Ramazzotti, Matteo; Poullet, Jean Baptiste; Massart, Sebastien; Collini, Silvia; Pieraccini, Giuseppe; Lionetti, Paolo (2010-08-02). "Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa". Proceedings of the National Academy of Sciences. 107 (33): 14691–14696. Bibcode:2010PNAS..10714691D. doi:10.1073/pnas.1005963107. ISSN 0027-8424. PMC 2930426. PMID 20679230.
- 1 2 3 4 5 Blanco-Míguez, Aitor; Gálvez, Eric J. C.; Pasolli, Edoardo; Filippis, Francesca De; Amend, Lena; Huang, Kun D.; Manghi, Paolo; Lesker, Till-Robin; Riedel, Thomas; Cova, Linda; Punčochář, Michal; Thomas, Andrew Maltez; Valles-Colomer, Mireia; Schober, Isabel; Hitch, Thomas C. A. (2023-11-08). "Extension of the Segatella copri complex to 13 species with distinct large extrachromosomal elements and associations with host conditions". Cell Host & Microbe. 31 (11). Elsevier: 1804–1819.e9. doi:10.1016/j.chom.2023.09.013. ISSN 1931-3128. PMC 10635906. PMID 37883976.
- ↑ Platenkamp, Amy; Mellies, Jay L. (2018-07-27). "Environment Controls LEE Regulation in Enteropathogenic Escherichia coli". Frontiers in Microbiology. 9 1694. Frontiers. doi:10.3389/fmicb.2018.01694. ISSN 1664-302X. PMC 6094958. PMID 30140259.
- ↑ McDaniel, T K; Jarvis, K G; Donnenberg, M S; Kaper, J B (1995-02-28). "A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens". Proceedings of the National Academy of Sciences. 92 (5): 1664–1668. Bibcode:1995PNAS...92.1664M. doi:10.1073/pnas.92.5.1664. ISSN 0027-8424. PMC 42580. PMID 7878036.
- ↑ Scher, Jose U; Sczesnak, Andrew; Longman, Randy S; Segata, Nicola; Ubeda, Carles; Bielski, Craig; Rostron, Tim; Cerundolo, Vincenzo; Pamer, Eric G; Abramson, Steven B; Huttenhower, Curtis; Littman, Dan R (2013-11-05). "Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis". eLife. 2 e01202. Bibcode:2013eLife...201202S. doi:10.7554/elife.01202. ISSN 2050-084X. PMC 3816614. PMID 24192039.
- ↑ Pianta, Annalisa; Arvikar, Sheila; Strle, Klemen; Drouin, Elise E.; Wang, Qi; Costello, Catherine E.; Steere, Allen C. (2017-04-07). "Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis". Arthritis & Rheumatology. 69 (5): 964–975. doi:10.1002/art.40003. ISSN 2326-5191. PMC 5406252. PMID 27863183.
- ↑ Haro, Carmen; García-Carpintero, Sonia; Rangel-Zúñiga, Oriol A.; Alcalá-Díaz, Juan F.; Landa, Blanca B.; Clemente, José C.; Pérez-Martínez, Pablo; López-Miranda, José; Pérez-Jiménez, Francisco; Camargo, Antonio (2017-11-07). "Consumption of Two Healthy Dietary Patterns Restored Microbiota Dysbiosis in Obese Patients with Metabolic Dysfunction". Molecular Nutrition & Food Research. 61 (12) 1700300. doi:10.1002/mnfr.201700300. ISSN 1613-4125. PMID 28940737.
- ↑ Marungruang, Nittaya; Tovar, Juscelino; Björck, Inger; Hållenius, Frida Fåk (2017-11-02). "Improvement in cardiometabolic risk markers following a multifunctional diet is associated with gut microbial taxa in healthy overweight and obese subjects". European Journal of Nutrition. 57 (8): 2927–2936. doi:10.1007/s00394-017-1563-3. ISSN 1436-6207. PMC 6267413. PMID 29098426.
- ↑ Tett, Adrian; Pasolli, Edoardo; Masetti, Giulia; Ercolini, Danilo; Segata, Nicola (2021-05-28). "Prevotella diversity, niches and interactions with the human host". Nature Reviews Microbiology. 19 (9): 585–599. doi:10.1038/s41579-021-00559-y. ISSN 1740-1526. PMC 11290707. PMID 34050328.