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Segundo may refer to:
- Segundo (Juana Molina album), 2000
- Segundo (Cooder Graw album), 2001
- Segundo, Ponce, Puerto Rico, a barrio in the municipio of Ponce, Puerto Rico
- Segundo River, a river in Cordoba, Argentina
- USS Segundo (SS-398), a United States submarine in commission from 1944 to 1970
- Segundo, Colorado, an unincorporated community of Colorado