Semaphorin 3E

Semaphorin 3E is a protein that in humans is encoded by the SEMA3E gene.

SEMA3E
Identifiers
Aliases	SEMA3E, M-SEMAH, M-SemaK, SEMAH, coll-5, semaphorin 3E
External IDs	OMIM: 608166; MGI: 1340034; HomoloGene: 8247; GeneCards: SEMA3E; OMA:SEMA3E - orthologs
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 A1 Start 14,075,290 bp End 14,306,703 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon islet of Langerhans gallbladder gastric mucosa synovial membrane urinary bladder synovial joint rectum prefrontal cortex ganglionic eminence Top expressed in lumbar spinal ganglion pontine nuclei decidua habenula gastrula right lung right lung lobe vestibular membrane of cochlear duct Region I of hippocampus proper substantia nigra More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding neuropilin binding semaphorin receptor binding chemorepellent activity Cellular component extracellular region extracellular space integral component of plasma membrane Biological process cell differentiation nervous system development multicellular organism development angiogenesis negative chemotaxis branching involved in blood vessel morphogenesis negative regulation of cell-matrix adhesion sprouting angiogenesis regulation of cell shape negative regulation of angiogenesis synapse organization semaphorin-plexin signaling pathway regulation of actin cytoskeleton reorganization neural crest cell migration positive regulation of cell migration negative regulation of axon extension involved in axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9723 20349 Ensembl n/a ENSMUSG00000063531 UniProt O15041 P70275 RefSeq (mRNA) NM_001178129 NM_012431 NM_011348 RefSeq (protein) NP_001171600 NP_036563 NP_035478 Location (UCSC) n/a Chr 5: 14.08 – 14.31 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Semaphorin are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins.

This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010].

Further reading

• Lalani SR, Safiullah AM, Molinari LM, Fernbach SD, Martin DM, Belmont JW (July 2004). "SEMA3E mutation in a patient with CHARGE syndrome". J. Med. Genet. 41 (7): e94. doi:10.1136/jmg.2003.017640. PMC 1735828. PMID 15235037.
• Kigel B, Varshavsky A, Kessler O, Neufeld G (September 2008). "Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells". PLOS ONE. 3 (9): e3287. Bibcode:2008PLoSO...3.3287K. doi:10.1371/journal.pone.0003287. PMC 2538586. PMID 18818766.
• Roodink I, Kats G, van Kempen L, Grunberg M, Maass C, Verrijp K, Raats J, Leenders W (December 2008). "Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression". Am. J. Pathol. 173 (6): 1873–81. doi:10.2353/ajpath.2008.080136. PMC 2626397. PMID 18974298.
• Sokolowski M, Wasserman J, Wasserman D (January 2010). "Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters". Mol. Psychiatry. 15 (1): 10–1. doi:10.1038/mp.2009.70. PMID 20029409.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Casazza A, Finisguerra V, Capparuccia L, Camperi A, Swiercz JM, Rizzolio S, Rolny C, Christensen C, Bertotti A, Sarotto I, Risio M, Trusolino L, Weitz J, Schneider M, Mazzone M, Mazzone M, Comoglio PM, Tamagnone L (August 2010). "Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice". J. Clin. Invest. 120 (8): 2684–98. doi:10.1172/JCI42118. hdl:2318/130565. PMC 2912191. PMID 20664171.
• Blanc V, Nariculam J, Munson P, Freeman A, Klocker H, Masters J, Williamson M (May 2011). "A role for class 3 semaphorins in prostate cancer". Prostate. 71 (6): 649–58. doi:10.1002/pros.21281. PMID 20949546. S2CID 34734719.
• Fukushima Y, Okada M, Kataoka H, Hirashima M, Yoshida Y, Mann F, Gomi F, Nishida K, Nishikawa S, Uemura A (May 2011). "Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice". J. Clin. Invest. 121 (5): 1974–85. doi:10.1172/JCI44900. PMC 3083763. PMID 21505259.
• Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML (July 2011). "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle". J. Biol. Chem. 286 (26): 23521–32. doi:10.1074/jbc.M111.220178. PMC 3123115. PMID 21555518.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.