Sempione may refer to:
- Passo del Sempione, Italian for Simplon Pass
- Sempione goat, breed of domestic goat from the mountains of Piemonte in north-western Italy
- Parco Sempione, park in Milan, Italy
- 231st Signal Battalion "Sempione", signals unit of the Italian Army
See also
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This disambiguation page lists articles associated with the title Sempione.
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