Senator Gillespie may refer to:
- Ann Gillespie (politician) (fl. 2010s–2020s), Illinois State Senate
- James Gillespie (U.S. politician) (1747–1805), North Carolina State Senate
- James J. Gillespie (1892–1959), Iowa State Senate
- Jerry Gillespie (politician) (1950–2011), Arizona State Senate
- Joseph Gillespie (1809–1885), Illinois State Senate