John Henry (Maryland politician) (1750–1798) was a U.S. Senator from Maryland from 1789 to 1797. Senator Henry may also refer to:
- Brad Henry (born 1963), Oklahoma State Senate
- Charles L. Henry (1849–1927), Indiana State Senate
- Daniel Maynadier Henry (1823–1899), Maryland State Senate
- Douglas Henry (1926–2017), Tennessee State Senate
- E. Stevens Henry (1836–1921), Connecticut State Senate
- John Henry (representative) (1800–1882), Illinois State Senate
- Margaret Rose Henry (born 1944), Delaware State Senate
- Morriss Henry (born 1931), Arkansas State Senate
- Pat Henry (politician) (1861–1933), Mississippi State Senate
- Paul B. Henry (1942–1993), Michigan State Senate
- William Wirt Henry (1831–1900), Virginia State Senate