Senator Locke may refer to:
- David H. Locke (1927–2019), Massachusetts State Senate
- Francis Locke Jr. (1776–1823), elected as a U.S. Senator from North Carolina in 1814, but resigned before qualifying
- James William Locke (1837–1922), Florida State Senate
- John Locke (Massachusetts politician) (1764–1855), Massachusetts State Senate
- Mamie Locke (born 1954), Virginia State Senate
- Matthew Fielding Locke (1824–1911), Texas State Senate
- Matthew Locke (U.S. Congress) (1730–1801), North Carolina State Senate
- Orrin Wiley Locke (1859–1951), Vermont State Senate
This disambiguation page lists articles associated with the title Senator Locke.
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