Senator Lyons may refer to:
- Edward H. Lyons (1855–1920), Wisconsin State Senate
- James Lyons (Virginia politician) (1801–1882), Virginia State Senate
- Owen P. Lyons (1849–1933), Maine State Senate
- Patrick H. Lyons (born 1953), New Mexico State Senate
- Virginia V. Lyons (born 1944), Vermont State Senate
- William J. Lyons Jr. (1921–2014), Connecticut State Senate