John S. Spence (1788–1840) was a U.S. Senator from Maryland from 1836 to 1840. Senator Spence may also refer to:
- Brent Spence (1874–1967), Kentucky State Senate
- Floyd Spence (1928–2001), South Carolina State Senate
- Nancy Spence (born 1936), Colorado State Senate
See also
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This disambiguation page lists articles associated with the title Senator Spence.
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