Senghor is a Serer surname - an ethnic group found in Senegal, Gambia and Mauritania. Personalities with this surname include:
- André Senghor (born 1986), Senegalese footballer
- Augustin Diamacoune Senghor (1928–2007), Senegalese Catholic priest and Casamance separatist
- Augustin Senghor, Senegalese politician
- Blaise Senghor (1932–1976), Senegalese film director, nephew of Léopold Sédar Senghor
- Constance Senghor (born 1963), Senegalese athlete
- Fatou Jagne Senghore, Gambian-Senegalese activist and lawyer
- Fatou Kandé Senghor (born 1971), Senegalese film director, writer, and photographer
- Lamine Senghor (1889–1927), Senegalese political activist
- Léopold Sédar Senghor (1906–2001), Senegalese poet, first president of Senegal and cultural theorist
- Louis Jacques Senghor (born 1952), Senegalese politician
- Robert Coleman-Senghor (1940–2011), American professor and politician
- Shaka Senghor, American college lecturer and author