- Barry Serafin
- Barry Serafin (golf course architect)
- Catharina Serafin, a patient on whom the first studies of electrical pacing were performed
- Enzo Serafin
- Felix Serafin
- Harald Serafin, Austrian opera singer
- Henryk Serafin
- Jakub Serafin
- Paulo Serafín
- Piotr Serafin (born 1974), Polish official
- Shan Serafin
- Silvio Sérafin
- Stefania Serafin
- Thomas J. Serafin
- Thom Serafin
- Tullio Serafin (1878–1968), Italian opera conductor