Serglycin, also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene.[5] It is primarily expressed in hematopoietic cells and endothelial cells,[6] and is the only known intracellular proteoglycan.[7]

SRGN
Identifiers
AliasesSRGN, PPG, PRG, PRG1, serglycin
External IDsOMIM: 177040; MGI: 97756; HomoloGene: 2043; GeneCards: SRGN; OMA:SRGN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002727
NM_001321053
NM_001321054

NM_011157
NM_001358965

RefSeq (protein)

NP_001307982
NP_001307983
NP_002718

NP_035287
NP_001345894

Location (UCSC)Chr 10: 69.09 – 69.1 MbChr 10: 62.33 – 62.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, and serves as a scaffold for the granzyme and perforin in granule-mediated apoptosis.[5][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122862Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020077Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SRGN serglycin".
  6. ^ Kolset SO, Tveit H (April 2008). "Serglycin--structure and biology". Cellular and Molecular Life Sciences. 65 (7–8): 1073–85. doi:10.1007/s00018-007-7455-6. PMC 11131666. PMID 18066495. S2CID 19422023.
  7. ^ Iozzo RV, Schaefer L (March 2015). "Proteoglycan form and function: A comprehensive nomenclature of proteoglycans". Matrix Biology. 42: 11–55. doi:10.1016/j.matbio.2015.02.003. PMC 4859157. PMID 25701227.
  8. ^ Metkar SS, Wang B, Aguilar-Santelises M, Raja SM, Uhlin-Hansen L, Podack E, Trapani JA, Froelich CJ (March 2002). "Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation". Immunity. 16 (3): 417–428. doi:10.1016/s1074-7613(02)00286-8. ISSN 1074-7613. PMID 11911826.

Further reading

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