Serrate RNA effector molecule homolog

Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is encoded by the SRRT gene.[5]

SRRT
Identifiers
AliasesSRRT, ARS2, ASR2, serrate, serrate, RNA effector molecule
External IDsOMIM: 614469; MGI: 1933527; HomoloGene: 9298; GeneCards: SRRT; OMA:SRRT - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001128852
NM_001128853
NM_001128854
NM_015908
NM_182800

NM_001109909
NM_001109910
NM_031405
NM_001359602

RefSeq (protein)

NP_001122324
NP_001122325
NP_001122326
NP_056992

NP_001103379
NP_001103380
NP_113582
NP_001346531

Location (UCSC)Chr 7: 100.88 – 100.89 MbChr 5: 137.29 – 137.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The SRRT gene product plays a role in RNA-mediated gene silencing (RNAi) by miRNAs. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural stem cell self-renewal, by directly binding to the SOX2 promoter and positively regulating its transcription. It enables the binding activity of the mRNA cap binding complex and the adaptor activity of certain protein molecules. It can be found in the nucleoplasm and is part of the ribonucleoprotein complex. It is involved in cell cycle progression around the S phase.[6]

It does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Diseases associated with SRRT include spondylocostal dysostosis and cerebral arteriopathy.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000087087Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037364Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ARS2 ARS2 protein".
  6. ^ "SRRT Gene". GeneCards. Retrieved 31 January 2023.

Further reading

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