Sethupathi is an Indian surname that may refer to
- Indian royalty
- Sethupathi, rulers of Ramnad
- Muthuramalinga Sethupathi II (1841–1873)
- Raja Rajeswara Sethupathi (1889–1929)
- Ramanatha Sethupathi (died 1979)
- Vijayaraghunatha Sethupathi (died 1720)
- Raghunatha Kilavan
- Bhaskara Sethupathi
- Others
- Rajkumar Sethupathi, Indian actor
- Shanmugha Rajeswara Sethupathi (1909–1967), Indian politician
- Vijay Sethupathi (born 1978), Indian film actor, producer, lyricist, and dialogue writer
- Latha (actress) or Latha Sethupathi, Indian actress, sister of Rajkumar Sethupathi