Seydou is the Francophonic-orthography variant of the Arabic name Sa'id, commonly used in West Africa.
Notable people with the name include:
- Seydou Bouda (born 1958), Burkinabé politician and US Ambassador
- Mohamed Seydou Dera (born 1986), Côte d'Ivoire footballer
- Seydou Diarra (1933–), Ivorian political figure, Prime Minister in 2000 and from 2003 to 2005
- Pape Seydou Diop (born 1979), Senegalese international footballer
- Seydou Doumbia (born 1987), Ivorian footballer
- Seydou Badjan Kanté (born 1981), former Ivory Coast-born football defender
- Seydou Keita (footballer) (born 1980), Malian professional footballer
- Seydou Keïta (photographer) (1921–2001), self-taught portrait photographer from Bamako
- Seydou Koné (born 1983), Ivorian professional football player
- Seydou Badian Kouyaté (born 1928), Malian writer and politician
- Seydou Njoya (1902–1992), ruled the Bamum people of Cameroon from 1933 to 1992
- Chris Seydou (1949–1994), Malian fashion designer
- Mayaki Seydou (born 1949), former Nigerien bantamweight boxer
- Seydou Traoré (born 1970), former Burkinabé footballer