Sh3 and sylf domain containing 1

SH3 and SYLF domain containing 1 is a protein that in humans is encoded by the SH3YL1 gene.

SH3YL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D8H
Identifiers
Aliases	SH3YL1, RAY, SH3 and SYLF domain containing 1
External IDs	OMIM: 617314; MGI: 1346118; HomoloGene: 31662; GeneCards: SH3YL1; OMA:SH3YL1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p25.3 Start 217,730 bp End 266,398 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 A2 Start 30,961,667 bp End 31,010,161 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule parotid gland skin of thigh body of pancreas hair follicle palpebral conjunctiva mucosa of colon mucosa of sigmoid colon jejunal mucosa oral cavity Top expressed in seminal vesicula epithelium of stomach transitional epithelium of urinary bladder saccule pyloric antrum fetal liver hematopoietic progenitor cell otic placode conjunctival fornix prostate secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatase binding protein binding phosphatidylinositol binding Cellular component ruffle membrane Biological process phosphatidylinositol biosynthetic process regulation of ruffle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26751 24057 Ensembl ENSG00000035115 ENSMUSG00000020669 UniProt Q96HL8 O08641 RefSeq (mRNA) NM_001159597 NM_001282682 NM_001282687 NM_015677 NM_001289480 NM_013709 RefSeq (protein) NP_001153069 NP_001269611 NP_001269616 NP_056492 NP_001276409 NP_038737 Location (UCSC) Chr 2: 0.22 – 0.27 Mb Chr 12: 30.96 – 31.01 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Asbach B, Ludwig C, Saksela K, Wagner R (2012). "Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome". PLOS ONE. 7 (6): e38540. Bibcode:2012PLoSO...738540A. doi:10.1371/journal.pone.0038540. PMC 3379994. PMID 22745667.
• Hasegawa J, Tokuda E, Tenno T, Tsujita K, Sawai H, Hiroaki H, Takenawa T, Itoh T (May 2011). "SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain". The Journal of Cell Biology. 193 (5): 901–16. doi:10.1083/jcb.201012161. PMC 3105542. PMID 21624956.
• Aoki N, Ito K, Ito M (May 2000). "A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle". The Journal of Investigative Dermatology. 114 (5): 1050–6. doi:10.1046/j.1523-1747.2000.00971.x. PMID 10771491.
• Shimomura Y, Aoki N, Ito K, Ito M (February 2003). "Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles". Journal of Dermatological Science. 31 (1): 43–51. doi:10.1016/s0923-1811(02)00140-8. PMID 12615363.