Shlesinger is a surname derived from Schlesien, the German name for Silesia.
Notable people with this surname include:
- Bernard Shlesinger (born 1960), American bishop
- Iliza Shlesinger (born 1983), American comedian
- Michael F. Shlesinger (born 1948), American physicist
- Miriam Shlesinger (1947–2012), US-Israeli linguist