Shugoshin 2

Shugoshin 2 (Shugoshin-2), also known as Shugoshin-like 2, is a protein which in humans is encoded by the SGO2 gene.

SGO2
Identifiers
Aliases	SGO2, TRIPIN, SGOL2, shugoshin 2
External IDs	OMIM: 612425; MGI: 1098767; HomoloGene: 51867; GeneCards: SGO2; OMA:SGO2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q33.1 Start 200,510,008 bp End 200,584,096 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C1.3|1 28.86 cM Start 58,035,130 bp End 58,065,058 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte sperm ventricular zone thymus testicle parietal pleura gonad ganglionic eminence buccal mucosa cell Top expressed in genital tubercle secondary oocyte zygote hand spermatocyte medial ganglionic eminence tail of embryo primary oocyte atrioventricular valve maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component chromosome cytosol chromosome, centromeric region nucleus kinetochore mitotic cohesin complex nucleoplasm nuclear body Biological process cell division chromosome segregation cell cycle meiotic sister chromatid cohesion, centromeric meiosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 151246 68549 Ensembl ENSG00000163535 ENSMUSG00000026039 UniProt Q562F6 Q7TSY8 RefSeq (mRNA) NM_001160033 NM_001160046 NM_152524 NM_001177867 NM_199007 RefSeq (protein) NP_001153505 NP_001153518 NP_689737 NP_001171338 NP_950172 Location (UCSC) Chr 2: 200.51 – 200.58 Mb Chr 1: 58.04 – 58.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Shugoshin-2 is one of the two mammalian orthologs of the Shugoshin/Mei-S322 family of proteins that regulate sister chromatid cohesion by protecting the integrity of a multiprotein complex named cohesin. This protective system is essential for faithful chromosome segregation during mitosis and meiosis, which is the physical basis of Mendelian inheritance.

Further reading

• Hartley JL; Temple GF; Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Kitajima TS, Sakuno T, Ishiguro K, et al. (2006). "Shugoshin collaborates with protein phosphatase 2A to protect cohesin". Nature. 441 (7089): 46–52. Bibcode:2006Natur.441...46K. doi:10.1038/nature04663. PMID 16541025. S2CID 4425074.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.