Sialic acid binding ig-like lectin 15

Sialic acid binding Ig-like lectin 15 (Siglec-15) is a protein that in humans is encoded by the SIGLEC15 gene. Siglec-15 is predominately expressed on osteoclasts, elevated levels of Siglec- 15 in the bone metastatic niche can promote tumor-induced osteoclastogenesis as well as suppress antigen-specific T cell responses. Researchers demonstrated that antibody blockade of the Siglec-15/sialic acid glycol-immune checkpoint axis can act as a potential treatment for breast cancer bone metastasis.

SIGLEC15
Identifiers
Aliases	SIGLEC15, CD33L3, HsT1361, SIGLEC-15, Sialic acid binding ig-like lectin 15, sialic acid binding Ig like lectin 15
External IDs	OMIM: 618105; MGI: 3646642; HomoloGene: 52643; GeneCards: SIGLEC15; OMA:SIGLEC15 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) Band 18q12.3 Start 45,825,675 bp End 45,844,094 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 E3 Start 78,086,829 bp End 78,100,610 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa buccal mucosa cell periodontal fiber pancreatic ductal cell tibia duodenum amniotic fluid mononuclear cell monocyte lactiferous duct Top expressed in embryo embryo ovary urinary bladder thymus More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 284266 620235 Ensembl ENSG00000197046 ENSMUSG00000091055 UniProt Q6ZMC9 A7E1W8 RefSeq (mRNA) NM_213602 NM_001101038 RefSeq (protein) NP_998767 NP_001094508 Location (UCSC) Chr 18: 45.83 – 45.84 Mb Chr 18: 78.09 – 78.1 Mb PubMed search
Wikidata
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Further reading

• Wang Y, Zhan X, et al. (January 22, 2024). "Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis". Proceedings of the National Academy of Sciences of the United States of America. 121 (5): e2312929121. doi:10.1073/pnas.2312929121. PMC 10835054. PMID 38252825.
• Takamiya R, Ohtsubo K, Takamatsu S, Taniguchi N, Angata T (February 2013). "The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway". Glycobiology. 23 (2): 178–87. doi:10.1093/glycob/cws139. PMID 23035012.
• Angata T, Tabuchi Y, Nakamura K, Nakamura M (August 2007). "Siglec-15: an immune system Siglec conserved throughout vertebrate evolution". Glycobiology. 17 (8): 838–46. doi:10.1093/glycob/cwm049. PMID 17483134.