Siege of Tbilisi may refer to:
- Siege of Tbilisi (627–628), successful siege of the city by the Byzantines and Turks
- Siege of Tbilisi (1122), successful siege of the city of Tbilisi, capital of the Emirate of Tbilisi, by the Georgians under King David IV
- Siege of Tbilisi (1386), successful Timurid attack on the capital of Kingdom of Georgia
- Battle of Krtsanisi, in 1795, part of Persian invasion of Kingdom of Kartli-Kakheti
- Siege of Tbilisi (1476),
Georgia was at least twice attacked by Uzun Hasan, the prince of the Aq Qoyunlu in 1476-7. Bagrat VI of Georgia, temporary ruler of most of Georgia at the time, had to make peace with the invaders, abandoning Tbilisi to the enemy
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