Simić (Serbian Cyrillic: Симић; pronounced [sǐːmitɕ]) is a Serbo-Croatian surname derived from the male given name Simo, found mainly among ethnic Serbs, but also Croats. It may refer to:
- Aleksa Simić (1800–1872), three-time prime minister
- Blagoje Simić (born 1960), Bosnian Serb war criminal
- Dušan Simić (1938–2023), Serbian-American poet best known as Charles Simic
- Goran Simić (born 1952), Bosnian poet
- Goran Simić (1953–2008), Serbian singer
- Jelena Simić (born 1992), Bosnian tennis player
- Jovan Simić Bobovac (1775–1831), Serbian prince
- Ljubiša Simić (born 1963), Serbian boxer
- Marko Simić (born 1987), Serbian-born Montenegrin football player
- Milorad Simić (born 1946), Bosnian-born Serbian linguist
- Valentina Simić (born 1994), Serbian dancer, hula-hooper, poet and writer - creator of Panda Time
- Vasilije Simić (1866–1931), Serbian lawyer, judge and attorney