Sir John Stonhouse, 2nd Baronet of Radley may refer to
- Sir John Stonhouse, 2nd Baronet (creation of 1628) (1601 – 14 June 1632, an English politician who sat in the House of Commons from 1628 to 1629.
- Sir John Stonhouse, 2nd Baronet (creation of 1670) (1639–1700), an English politician who sat in the House of Commons at various times between 1675 and 1690.