Sirajuddin (Arabic: سراج الدين) may refer to:
- Munabbih ibn Kamil ibn Sirajud-Din Dhee Kibaar Abu-Abdullah al-Yamani al-San'ani, Persian companion of Muhammad
- Usman Serajuddin (1258–1357), court scholar of the Bengal Sultanate
- Abu Zafar Sirajuddin Muhammad Bahadur Shah Zafar, Bahadur Shah II (1775–1862), last of the Mughal emperors in India
- Fouad Serageddin (1910–1999), leader of Egypt's Wafd Party
- Abib Sarajuddin (born c. 1942) Afghan held in Guantanamo Bay detention camps, Serial Number 458
- Tuanku Syed Sirajuddin of Perlis (born 1943), Raja of Perlis, Yang di-Pertuan Agong of Malaysia
- Sirajuddin Haqqani (born c. 1970), Pashtun warlord and military leader
- Sirajeddine Chihi (born 1970), Tunisian footballer
- Sirajuddin Hamid Yousuf, Sudanese diplomat, Sudanese Ambassador to the Russian Federation
- Sirajuddin Muhammad "Din" Syamsuddin, Indonesian politician and formerly the Chairman of Muhammadiyah for two terms from 2005 to 2010 and 2010 to 2015.